Using Direct Commander, it's possible to quickly fix spelling errors and replace words and negative words in keywords, even if they are related to different ad groups or campaigns:
Indicate the replacement parameters in the Replace in keywords window.
You can search for the fragment at the beginning, end, or in any place of the value field. The new fragment can replace the found fragment or be added before or after it.
You can make changes in all (or selected) keywords without searching for the fragment. To do so, do not click “Search”. Instead, click “All values”. The new fragment can replace the previous field value or be added to the beginning or end of the value.
You can specify the set of keyword fields and other search parameters in advanced settings.
Replacement can be executed in all ads or just in one.